Kinetic modeling of four folates in a model solution at different temperatures and <scp>pH</scp> to mimic their behavior in foods during processing

This study aims to generate new kinetic data on 4 folate forms, namely folic acid (FA), 5-methyl-tetrahydrofolate (5MTHF), 10-formylfolic (10FFA) and tetrahydrofolate (THF) in the same conditions: model media at three temperatures (60°C, 80°C, 100°C) pH values (3, 5, 7). For four degradation could be described using a first-order model. At 100°C 3, rates were 2.8 × 10−2, 1.6 1.8 10−3, 10−5 min−1 for 5MTHF, THF, 10FFA FA respectively. Therefore, reactivity modulated by factor of 2, 10, up 200-fold acid. increase had positive effect retention THF has lowest impact 5MTHF degradation. Product formation from 10 FFA studied multiresponse modeling. Both vitamers generated intermediary products that accumulated differently as function pH. These results give comprehension insights into during food processing formulation (pH lever) process (temperature lever). Practical Applications article brings vitamins B9 cooking. Folate is group vitamins, sharing similar molecular structure while having different bioactivity. The lack diet can lead severe health disorder. Their human metabolization thermic influenced factors, including their own structure. it high importance understand how each form degraded determine best conditions preserve them. Our work, mediums, allowed identify forms (including pathway) order more guidance, offers an operational tool manufacturer potential folates pH, temperature vitamer composition.